LymphedemaV1, Main, Exploration, bibRecord, 006912

The Lymphatic System in Health and Disease

Identifieur interne : 006912 ( Main/Exploration ); précédent : 006911; suivant : 006913

The Lymphatic System in Health and Disease

Auteurs : Leah N. Cueni ; Michael Detmar

Source :

Lymphatic research and biology [ 1539-6851 ] ; 2008.

RBID : PMC:3572233

Descripteurs français

KwdFr :
- Animaux, Humains, Inflammation (anatomopathologie), Lymphangiogenèse, Lymphoedème (anatomopathologie), Modèles biologiques, Métastase lymphatique, Phénotype, Souris, Système immunitaire, Système lymphatique (physiologie), Tumeurs (anatomopathologie), Vaisseaux lymphatiques (anatomopathologie).
MESH :
- anatomopathologie : Inflammation, Lymphoedème, Tumeurs, Vaisseaux lymphatiques.
- physiologie : Système lymphatique.
- Animaux, Humains, Lymphangiogenèse, Modèles biologiques, Métastase lymphatique, Phénotype, Souris, Système immunitaire.

English descriptors

KwdEn :
- Animals, Humans, Immune System, Inflammation (pathology), Lymphangiogenesis, Lymphatic Metastasis, Lymphatic System (physiology), Lymphatic Vessels (pathology), Lymphedema (pathology), Mice, Models, Biological, Neoplasms (pathology), Phenotype.
MESH :
- pathology : Inflammation, Lymphatic Vessels, Lymphedema, Neoplasms.
- physiology : Lymphatic System.
- Animals, Humans, Immune System, Lymphangiogenesis, Lymphatic Metastasis, Mice, Models, Biological, Phenotype.

Abstract

The lymphatic vascular system has an important role in the regulation of tissue pressure, immune surveillance and the absorption of dietary fat in the intestine. There is growing evidence that the lymphatic system also contributes to a number of diseases, such as lymphedema, cancer metastasis and different inflammatory disorders. The discovery of various molecular markers allowing the distinction of blood and lymphatic vessels, together with the availability of a increasing number of in vitro and in vivo models to study various aspects of lymphatic biology, has enabled tremendous progress in research into the development and function of the lymphatic system. This review discusses recent advances in our understanding of the embryonic development of the lymphatic vasculature, the molecular mechanisms mediating lymphangiogenesis in the adult, the role of lymphangiogenesis in chronic inflammation and lymphatic cancer metastasis, and the emerging importance of the lymphatic vasculature as a therapeutic target.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572233

DOI: 10.1089/lrb.2008.1008
PubMed: 19093783
PubMed Central: 3572233

Affiliations:

Le document en format XML

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<term>Lymphatic System (physiology)</term>
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<term>Humains</term>
<term>Inflammation (anatomopathologie)</term>
<term>Lymphangiogenèse</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Modèles biologiques</term>
<term>Métastase lymphatique</term>
<term>Phénotype</term>
<term>Souris</term>
<term>Système immunitaire</term>
<term>Système lymphatique (physiologie)</term>
<term>Tumeurs (anatomopathologie)</term>
<term>Vaisseaux lymphatiques (anatomopathologie)</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Inflammation</term>
<term>Lymphoedème</term>
<term>Tumeurs</term>
<term>Vaisseaux lymphatiques</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammation</term>
<term>Lymphatic Vessels</term>
<term>Lymphedema</term>
<term>Neoplasms</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Système lymphatique</term>
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<term>Humans</term>
<term>Immune System</term>
<term>Lymphangiogenesis</term>
<term>Lymphatic Metastasis</term>
<term>Mice</term>
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<term>Phenotype</term>
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<term>Humains</term>
<term>Lymphangiogenèse</term>
<term>Modèles biologiques</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">The lymphatic vascular system has an important role in the regulation of tissue pressure, immune surveillance and the absorption of dietary fat in the intestine. There is growing evidence that the lymphatic system also contributes to a number of diseases, such as lymphedema, cancer metastasis and different inflammatory disorders. The discovery of various molecular markers allowing the distinction of blood and lymphatic vessels, together with the availability of a increasing number of <italic>in vitro</italic>
 and <italic>in vivo</italic>
 models to study various aspects of lymphatic biology, has enabled tremendous progress in research into the development and function of the lymphatic system. This review discusses recent advances in our understanding of the embryonic development of the lymphatic vasculature, the molecular mechanisms mediating lymphangiogenesis in the adult, the role of lymphangiogenesis in chronic inflammation and lymphatic cancer metastasis, and the emerging importance of the lymphatic vasculature as a therapeutic target.</p>
</div>
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Serveur d'exploration sur le lymphœdème

The Lymphatic System in Health and Disease

The Lymphatic System in Health and Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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